Today's Parola del Giorno is the expression non poterne più (di), which means to be fed up (with).
Note the use of the pronoun ne!
The expression can be used on its own:
Non ne posso più
I've had it!
The expression can also be used with the preposition di, which provides more explanation about exactly what is bothering you, as in our example below:
Non ne posso più della tua maleducazione e arroganza! Questa è casa mia e ci sono delle regole: se ti cucini, poi devi anche pulire!
I am fed up with your rudeness and arrogance! This is my home, and there are some rules: if you cook, then you also have to clean!