il fine settimana
Parola del giorno | Word of the day
In Italian, you can talk about the weekend using the English word il weekend.
Or you can use the expression il fine settimana, which also means weekend.
Most of the dictionaries I consulted (Treccani, Zanichelli, Oxford) note that you can also say la fine settimana, but the masculine form is more common I am told.
If you are interested in learning more about the grammar, you can find a short discussion at Treccani. The TL;DR version is that the masculine form is preferred.